JX401, A p38 Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
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چکیده
Y.F., A. S., E.R.B. and D. E.: Jexys Pharmaceuticals Ltd., POB 39024, Jerusalem 91390, Israel. D. E. and I. M.: The Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. S.G. and E. B.: Department of Biochemistry, Rappaport Institute, for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology. P.O. Box 9649, Haifa 31096 Israel. Molecular Pharmacology Fast Forward. Published on July 17, 2006 as doi:10.1124/mol.106.022962
منابع مشابه
JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.
In vivo screening of compounds for potential pharmacological activity is more advantageous than in vitro screening. In vivo screens eliminate the isolation of compounds that cannot cross biological membranes, are cytotoxic, or are not specific to the target. However, animal-based or even cell-based systems are usually expensive, time-consuming, and laborious. Here we describe the identification...
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تاریخ انتشار 2006